неделя, 14 март 2010 г.

Scientific interests: Organic Chemistry, Amino acids, Biomolecule synthesis and investigation(Peptides, Carbohydrates, Glycopeptide) Methods for separation and analysis of organic compounds (HPLC, GC-MS, etc.).

Professional experience: Organic and bioorganic chemistry; HPLC – application for analysis of biological active organic compounds

PUBLICATIONS (total number)____________________ _____________

Papers in international peer reviewed journals

1. Synthesis of new analogues of antistasin and ghilantens, Vezenkov Lyubomir, Danalev Dantcho and Grigorova Boryana, Collection, 2003, v.6, 115-118

2. Synthesis and structure-activity relationship of new analogues of antistasin, Danalev Dantcho, Vezenkov Lyubomir and Grigorova Boryana, J. Pept. Sci., 2004, 10, 27-36

3. Design, synthesis and structure-activity relationship of a series of fragment analogues of antistasin (ATS) and ghilantens (GLS), Dantcho Danalev, Lyubomir Vezenkov and Boryana Grigorova, Bioorg&Med. Chem. Lett., 2005, vol. 15, 4217-4220

4. Investigation of kinetic parameters in vitro of serine proteinases included in the blood coagulation cascade, Dantcho Danalev, Lyubov Yotova and Lyubomir Vezenkov, Protein & Peptide Letters, 2006, vol. 13 (6), 535-537

5. Synthesis of two peptide mimetics as markers for chemical changes of wool’s keratin during skin unhairing process, Dantcho Danalev, Margarita Koleva, Dimitrina Ivanova, Lyubomir Vezenkov and Nikolay Vassilev, Protein & Peptide Letters, 2008, 15 (4), 341-345

6. Synthesis and characterization of new galanthamine derivatives comprising peptide moiety - Lyubomir T. Vezenkov, Maria G. Georgieva, Dantcho L. Danalev, Tchavdar B. Ivanov, Galya I. Ivanova, Protein & Peptide Letters, 2009, 16 (9), 1024-1028

7. From molecule to sexual behavior: The role of the neuropentapeptide Proctolin in acoustic communication in the male grasshopper Chorthippus biguttulus, Stoyan Vezenkov and Dantcho Danalev, European Journal of Pharmacology (2009) 216, 57-60

8. New peptide analogues of b-secretase inhibitor OM 99-2, modified in P3-position - Ivan Ivanov, Lyubomir Vezenkov and Dantcho Danalev, Collection of Czechoslovak Chemical Communications 2010, in press

9. Design, synthesis and structure-activity relationship of new 109-116 fragment analogues of antistasin and ghilantens - Dantcho L. Danalev, Lyubomir T. Vezenkov, Valentin Lozanov, Anastasia Bakalova, International Journal of Peptide Research and Therapeutics, 2010, in press


Communications in the Proceedings of International and National Conferences

10. Design and synthesis of antistatin and ghilantens analogues with anticoagulant activity, D. Danalev, L. Vezenkov and N. Pentcheva, 1998, Proceedings of the 25-th European Peptide Symposium, 609

11. Design and synthesis of analogues of antistasin with potential anticoagulant activity, Danalev Dantcho, Vezenkov Lyubomir and Pentcheva Nevena, Peptides 2000, Proceedings of the 26-th European Peptide Symposium, 805-806

12. Analogues of antistasin, ghilantens and anticaogulant peptide. Design, synthesis and biological activity, Lyubomir Vezenkov, Emilia Naydenova, Dantcho Danalev and Nevena Pentchva, Collection of jubilee session “15 years Technological Collage – Razgrad” v.38 (10), 2001, 49-54

13. Design, synthesis and biological activity of new analogues of antistasin, Danalev Dantcho, Vezenkov Lyubomir and Grigorova Boryana, Peptides 2002, Proceedings of the 27-th European Peptide Symposium, 458-459

14. Structure-activity relationship of short analogues of antistasin (ATS) and ghilantens (GLS) including different basic amino acids in 109 position, Grigorova Boryana, Danalev Dantcho and Vezenkov Lyubomir, Peptides 2004, Proceedings of the 28-th European Peptide Symposium, 908-909

15. Investigation of kinetic parameters in vitro of serine proteinases included in the blood coagulation cascade, Lyubov Yotova, Dantcho Danalev and Lyubomir Vezenkov, Proceeding of International Symposium BioPS’2005, October 25-26, Sofia, III.13-III.20

16. Investigation of the inhibiting effect of Phe-Ile-Arg-Pro-Lys-Arg-Lys on the serine proteinases included in the blood coagulation cascade, D. Danalev, L. Yotova, L. Vezenkov, Bulgarian Chemical Communications, Volume 38, Number 1 (pp. 3–6) 2006, Proceeding of 4-th Bulgarian Peptide Symposium

17. New fragment analogues of antistasin’s (ATS) active site – design, synthesis and structure-activity relationship, D.Danalev and L.Vezenkov, Peptides 2006, Proceedings of the 29-th European Peptide Symposium, 148-149

18. New amide analogues of antistasin isoform 2 and 3 – Dantcho Danalev and Lyubomir Vezenkov, 2008, Proceedings of the 30-th European Peptide Symposium (2008), v. 14 (8), 66

19. Efficient chemical synthesis of amides and peptides using phosphonic acid/alkylene oxide chemistry – S. Bayryamiv, D. Danalev, N. Vassilev, 2008, Proceedings of the 30-th European Peptide Symposium (2008), v. 14 (8), 66

20. Design and synthesis of new peptide mimetics with potential β-secretase inhibition activity – I. Ivanov, D.Danalev and L. Vezenkov, 2008, Proceedings of the 30-th European Peptide Symposium, in press

21. Design, synthesis and anticoagulant studies of new antistasin isoform 2 and 3 analogues - D. L. Danalev and L. T.Vezenkov, Bulgarian Chemical Communications, 2008, Proceeding of the 5-th Bulgarian Peptide Symposium, in press

22. Synthesis of two peptide mimetics as markers for chemical changes of wool’s keratin during skun unhairing process and comparision of the wool quality obtained by ecological methods for skins unhairing - M. Koleva, D. Danalev, D. Ivanova, L. Vezenkov and N. Vassilev, Bulgarian Chemical Communications, 2008, Proceeding of the 5-th Bulgarian Peptide Symposium, in press

23. Synthesis of model peptide substrates and investigation of the reaction of their phenylacetyl protecting group enzyme transformation by means of penicillin G acylase – D. Danalev and L. Yotova, Bulgarian Chemical Communications, 2008, Proceeding of the 5-th Bulgarian Peptide Symposium, in press

24. New peptide mimetics with potential β-secretase inhibition activity – I. Ivanov, D.Danalev and L. Vezenkov, Bulgarian Chemical Communications, 2008, Proceeding of the 5-th Bulgarian Peptide Symposium, in press


Other publications


25. Synthesis of new analogues of antistasin containing the active sequence Phe-Ile-Arg, Danalev Dantcho, Vezenkov Lyubomir, Chausheva Rumyana and Grigorova Boryana, Comptes rendus de l’Academie bulgare des Sciences, v.55 (11), 2002, 55-59

26. Comparison of some dates of two unhairng methods of sheep skins for dressing, Koleva M., Pepeldjiska N., Ivanova D., Vezenkov L., Danalev D., J. UCTM, (2003), 2, 385-388

Patents

1. Vezenkov L., Georgieva M., Danalev D., Ivanov, Tchavdar B., Bakalova A., Hristov K., Danchev N., Mitev V., Galanthamine derivatives, methods for synthesis and using for treatment of neurodegenerative illness - BG 110141/23. 05. 2008

2. Vezenkov L., Georgieva M., Danalev D., Ivanov, Tchavdar B., Bakalova A., Hristov K., Danchev N., Mitev V., Galanthamine derivatives, methods for synthesis and using for treatment of neurodegenerative illness – 2008, EP 09472001.8

FORMATION AND/OR RESEARCH PROJECTS (2003-2008) ___________________

National Research Fund

  1. Synthesis of peptide with potential anticoagulant activity and their biological characterization – team member
  2. Design and synthesis of peptides with potential anticoagulant activity - team member
  3. Anticoagulant peptides – design, synthesis and biological investigations - team member
  4. Design, synthesis and biological activity of new peptide mimetics with γ – secretase, monoaminooxidase and antiaggregative inhibition activities - team member
  5. Lipid class and fatty-acid ingredients investigations of fish oil’s extracts by means of GC-MS - team member
  6. Glycofuranopeptides as new potential anti-parasitic drugs – team leader (2009-2010)

Research fund of UCTM

  1. Design of hybrid structures with anti-HIV activities –contract with research centre of UCTM, 2003 – team leader
  2. Investigations on the kinetic and mechanism of enzymatic transformation of newly synthesized peptide mimetics contained phenylacetyl protecting groups, 2004 – team leader
  3. New analogues of antistasin – design, synthesis and structure-activity relationship, 2006 – team leader
  4. Anticoagulant peptides – synthesis and biological activity investigation - team member
  5. Synthesis of tacrin derivatives with expected both acetylcholinesterase and γ-secretase inhibition activities, 2008 – team leader

Industrial contracts

  1. Bioavailability investigation of novfilin retard – 100 mg, Farmacia AD – Dupnitza - team member
  2. Introducing of method IEC 1198 for determination of furan derivatives in worked transformer oils – National Electrical Company, 2001 – team member
  3. Concentration determination of furan derivatives dissolved in transformer oils - National Electrical Company, 2002 – team member
  4. Bioavailability investigation of Primolut Nor – 5 mg - Farmacia AD – Dupnitza, 2003 – team member
  5. Synthesis of galanthamin derivatives, AChE and γ–secretase inhibitors NIChPhI – AD, 2003 – team member
  6. Biological activity investigation of new galanthamin derivatives - SoPharma AD – Sofia, 2005 – team member


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